Federal State Budgetary Institution of Higher Professional Education "Central State Medical Academy" (Department of Anesthesiology and Resuscitation, Professor)
Russian Federation
Federal State Budgetary Institution of Higher Professional Education "Central State Medical Academy" (Department of Radiology, Associate Professor)
Russian Federation
Federal State Budgetary Institution of Higher Professional Education "Central State Medical Academy" (Department of Anesthesiology and Resuscitation, Head of Department)
Russian Federation
Necrotizing soft tissue infection is a potentially dangerous infection often resulting in disability and mortality. Polymorphism of clinical symptoms often makes it difficult to diagnose necrotizing soft tissue infection in the early stages of the disease. The treatment tactics in patients with necrotizing soft tissue infection shall be active and include early surgical intervention and antibiotic therapy. Multidisciplinary approach is a key to successful treatment of the patients with this pathology.
necrotizing soft tissue infection, sepsis, organ dysfunction, amputation
1. Huang K.F., Hung M.H., Lin Y.S. et al. Independent predictors of mortality for necrotizing fasciitis: a retrospective analysis in a single institution. J Trauma. – 2011. – 71(2): 467–473. doi:https://doi.org/10.1097/TA.0b013e318220d7fa
2. Gundersen I.M., Bruun T., Almeland S.K. et al. Necrotising soft tissue infections. Tidsskr Nor Laegeforen. – 2024. – 144(3). doi:https://doi.org/10.4045/tidsskr.23.0720
3. Sartelli M., Coccolini F., Kluger Y. et al. WSES/GAIS/WSIS/SIS-E/AAST global clinical pathways for patients with skin and soft tissue infections. World J Emerg Surg. – 2022. – 17(1): 3. doi:https://doi.org/10.1186/s13017-022-00406-2
4. Nawijn F., Hietbrink F., Peitzman A.B. et al. Necrotizing Soft Tissue Infections, the Challenge Remains. Front Surg. – 2021; 8: 721214. doi:https://doi.org/10.3389/fsurg.2021.721214
5. Bonne S.L., Kadri S.S. Evaluation and Management of Necrotizing Soft Tissue Infections. Infect Dis Clin North Am. – 2017; 31(3): 497–511. doi:https://doi.org/10.1016/j.idc.2017.05.011
6. Peetermans M., de Prost N., Eckmann C. et al. Necrotizing skin and soft-tissue infections in the intensive care unit. Clin Microbiol Infect. – 2020; 26(1): 8-17. doi:https://doi.org/10.1016/j.cmi.2019.06.031
7. Miopatii v praktike klinicista: rukovodstvo dlya vrachey / pod red. I.N. Pasechnika, S.A. Berns, V.V. Boyarinceva. – Moskva: GEOTAR-Media. – 2023. – 448 s. doi:https://doi.org/10.33029/9704- 7648-2-MRK-2023-1-448.
8. Moriyama K., Nishida O. Targeting Cytokines, Pathogen-Associated Molecular Patterns, and Damage-Associated Molecular Patterns in Sepsis via Blood Purification. Int J Mol Sci. – 2021; 22(16): 8882. doi:https://doi.org/10.3390/ijms22168882.
9. Goh T., Goh L.G., Ang C.H. et al. Early diagnosis of necrotizing fasciitis. Br J Surg. – 2014; 101(1): e119-125. doi:https://doi.org/10.1002/bjs.9371
10. Fernando S.M., Tran A., Cheng W. et al. Necrotizing Soft Tissue Infection: Diagnostic Accuracy of Physical Examination, Imaging, and LRINEC Score: A Systematic Review and Meta-Analysis. Ann Surg. – 2019; 269(1): 58–65. doi:https://doi.org/10.1097/SLA.0000000000002774
11. Wong C.H., Khin L.W., Heng K.S. et al. The LRINEC (Laboratory Risk Indicator for Necrotizing Fasciitis) score: a tool for distinguishing necrotizing fasciitis from other soft tissue infections. Crit Care Med. – 2004; 32(7): 1535–1541. doi:https://doi.org/10.1097/01.ccm.0000129486.35458.7d
12. Cui Z., Lu S., Bai Y., Sun X. et al. Necrotizing soft tissue infection: clinical characteristics, diagnosis, and management of 32 cases in Beijing. J Int Med Res. – 2021; 49(5). doi:https://doi.org/10.1177/03000605211018442
13. Kadri S.S., Swihart B.J., Bonne S.L. et al. Impact of Intravenous Immunoglobulin on Survival in Necrotizing Fasciitis With Vasopressor-Dependent Shock: A Propensity Score-Matched Analysis From 130 US Hospitals. Clin Infect Dis. – 2017; 64(7): 877–885. doi:https://doi.org/10.1093/cid/ciw871
14. Bulger E.M., May A.K., Robinson B.R.H. et al. ACCUTE Study Investigators. A Novel Immune Modulator for Patients With Necrotizing Soft Tissue Infections (NSTI): Results of a Multicenter, Phase 3 Randomized Controlled Trial of Reltecimod (AB 103). Ann Surg. – 2020; 272(3): 469–478. doi:https://doi.org/10.1097/SLA.0000000000004102
