Russian Federation
Russian Federation
Russian Federation
Russian Federation
Vladivostok, Vladivostok, Russian Federation
The paper presents intermediate results of the study of a possibility to use neuroimmune markers for diagnostics of cognitive impairments in middle-aged and elderly people. Reliable association of the neurocognitive testing results and serum levels of the neuroimmune markers is demonstrated. Similarity of neurocognitive impairment pathogenesis in case of various types of lesions of both infectious and non-infectious etiology is discussed.
cognitive impairments, neuropeptides, growth factors, diagnostics
1. Liu W., Wang X., O'Connor M., Wang G., Han F. Brain-Derived Neurotrophic Factor and Its Potential Therapeutic Role in Stroke Comorbidities // Neural Plast. – 2020; 2020:1969482. Doi:https://doi.org/10.1155/2020/1969482
2. Saylor D., Dickens A.M., Sacktor N. et al. HIV-associated neurocognitive disorder-pathogenesis and prospects for treatment // Nat Rev Neurol. – 2016; 12(4):234–248. Doi:https://doi.org/10.1038/nrneurol.2016.27
3. Borrajo A., Spuch C., Penedo M.A., Olivares J.M., Agís-Balboa R.C. Important role of microglia in HIV-1 associated neurocognitive disorders and the molecular pathways implicated in its pathogenesis // Ann Med. – 2021; 53(1):43–69. Doi:https://doi.org/10.1080/07853890.2020.1814962
4. Wang H., Li D., Li S. et al. Physical activity interventions for post-stroke cognitive recovery: a systematic review and network meta-analysis of comparative effects // Front Neurol. – 2025; 16:1646328. Doi:https://doi.org/10.3389/fneur.2025.1646328
5. Huang Y., Wang Q., Zou P., He G., Zeng Y., Yang J. Prevalence and factors influencing cognitive impairment among the older adult stroke survivors: a cross-sectional study // Front Public Health. – 2023; 11:1254126. Doi:https://doi.org/10.3389/fpubh.2023.1254126
6. Gavioli E., Mantelli F., Cesta M.C., Sacchetti M., Allegretti M. The History of Nerve Growth Factor: From Molecule to Drug // Biomolecules. – 2024; 14(6):635. Doi:https://doi.org/10.3390/biom14060635
7. Gallucci L., Sperber C., Monsch A.U., Klöppel S., Arnold M., Umarova R.M. Improving diagnostic accuracy of the Montreal Cognitive Assessment to identify post-stroke cognitive impairment // Sci Rep. – 2024; 14(1):20125. Doi:https://doi.org/10.1038/s41598-024-71184-x
8. Kostenko E.V., Petrova L.V., Egorov P.D., Pogonchenkova I.V., Filippov M.S. Neyrotroficheskie faktory kak markery vosstanovleniya posle insul'ta: obzor // Vestnik vosstanovitel'noy mediciny. – 2025. – T. 24. – № 3. – S. 123–139. Doi:https://doi.org/10.38025/2078-1962-2025-24- 3-123-139
9. Walczak P., Ji X., Li S., Boltze J. Protecting the brain from multifaceted damage and promoting recovery // Neuroprotection. – 2025. – V. 3. – № 1. – P. 1–4. Doi:https://doi.org/10.1002/nep3.70003
10. Campos B., Choi H., DeMarco A.T. et al. Rethinking Remapping: Circuit Mechanisms of Recovery after Stroke // The Journal of Neuroscience. – 2023. – V. – 43. – N 45. – P. 7489–7500. Doi:https://doi.org/10.1523/JNEUROSCI.1425-23.2023
11. Kantur T.A., Hmeleva E.V., Kolesnikova Yu.B., Barzeeva Zh.B. Effektivnost' funkcional'noy elektrostimulyacii nizhnih konechnostey u pacientov, perenesshih insul't // Tihookeanskiy medicinskiy zhurnal. – 2023; (4):21–25. https: //doi.org/10.34215/1609-1175-2023-4-21-25
