Federal State Budgetary Institution of Higher Professional Education "Central State Medical Academy" (Department of Anesthesiology and Resuscitation, Professor)
Russian Federation
Federal State Budgetary Institution of Higher Professional Education "Central State Medical Academy" (Department of Anesthesiology and Resuscitation, Head of Department)
Russian Federation
The extracorporeal detoxification methods are widely used in everyday practice. Contact between blood and surfaces of the extracorporeal blood circuit, columns/dialyzers initiates coagulation. Activation of the blood coagulation system can result in development of both thrombosis and hemorrhagic complications. This problem is solved through the use of anticoagulants which allow conducting long sessions of extracorporeal detoxification methods, and this survey focuses on principal types of anticoagulants actually used for extracorporeal blood detoxification.
: anticoagulation, extracorporeal detoxification methods, heparin, regional citrate anticoagulation.
1. Willers A., Arens J., Mariani S. et al. New Trends, Advantages and Disadvantages in Anticoagulation and Coating Methods Used in Extracorporeal Life Support Devices // Membranes (Basel). – 2021; 11(8): 617 Doi:https://doi.org/10.3390/membranes11080617
2. Mendibaev M.S., Lyhin V.N., Rabotinskiy S.E., Ageev P.V. Ekstrakoproral'noe ochischenie krovi v intensivnoy terapii / Pod red. S.I. Reya, A.Yu. Bulganova. – Moskva: GEOTAR-Media. – 2024 – 368 s.: il. Doi:https://doi.org/10.33029/9704-8714-3-EKS-2024-1-368
3. Shilo V.Yu. Nizkomolekulyarnye gepariny v gemodialize: mnogoletniy opyt primeneniya dalteparina // Klinicist. – 2008; 2: 55–61.
4. Mendibaev M.S., Rabotinskiy S.E. Farmakologicheskie metody stabilizacii krovi v ekstrakorporal'nom konture // Vestnik anesteziologii i reanimatologii. – 2023; 20(1): 81–88. Doi:https://doi.org/10.24884/2078-5658-2023-20-1-81-88
5. Devenport E. Sovremennye principy antikoagulyacii u bol'nyh v kriticheskom sostoyanii, nuzhdayuschihsya v ekstrakorporal'noy terapii. / V kn.: Rukovodstvo po ekstrakorporal'nomu ochischeniyu krovi v intensivnoy terapii // Pod red. L.A. Bokeriya, M.B. Yarustovskogo. – Moskva: NCSSH im. A.N. Bakuleva MZ RF. – 2016: 279–299.
6. Strokov A.G., Poz Ya.L. Antikoagulyaciya pri zamestitel'noy pochechnoy terapii: klassicheskie podhody i novye vozmozhnosti // Vestnik transplantologii i iskusstvennyh organov. – 2010; 12(4): 80–85.
7. Milovanov Yu.S., Dobromyslov I.A., Milovanova S.Yu. Tromboprofilaktika pri gemodialize // Consillium medicum. – 2017; 19 (7.2 Hirurgiya): 51–54. Doi:https://doi.org/10.26442/2075-1753_19.7251-54
8. Singh S. Anticoagulation during Renal Replacement Therapy // Indian J Crit Care Med. – 2020; 24 (Suppl 3): S112–S116. Doi:https://doi.org/10.5005/jp-journals-10071-23412
9. Kameda S., Maeda A., Maeda S. et al. Dose of nafamostat mesylate during continuous kidney replacement therapy in critically ill patients: a two-centre observational study // BMC Nephrol. – 2024; 25(1): 69 Doi:https://doi.org/10.1186/s12882-024-03506-0
10. Liu D., Zhao J., Xia H. et al. Nafamostatmesylate versus regional citrate anticoagulation for continuous renal replacement therapy in patients at high risk of bleeding: a retrospective single-center study // Eur J Med Res. – 2024; 29(1): 72 Doi:https://doi.org/10.1186/s40001-024-01660-7
11. Petros S. Lepirudin in the management of patients with heparin-induced thrombocytopenia // Biologics. – 2008; 2(3):481–490. Doi:https://doi.org/10.2147/btt.s3415
12. Roberts T.R., Garren M.R.S., Handa H., Batchinsky A.I. Toward an artificial endothelium: Development of blood-compatible surfaces for extracorporeal life support // J Trauma Acute Care Surg. – 2020; 89(2S Suppl 2): S59–S68. Doi:https://doi.org/10.1097/TA.0000000000002700



