Federal State Budgetary Institution "Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies of the Federal Medical and Biological Agency" (Department of Dermatovenereology and Cosmetology, Professor)
Russian Federation
Russian Federation
Russian Federation
Moscow, Moscow, Russian Federation
Long and persistent course of chronic spontaneous urticaria (CSU) as well as low efficiency of diagnostics and treatment increase social importance of further studies of the pathophysiological mechanisms of CSU which could help to find new therapeutic targets. The Toll-like receptors (TLRs) which belong to the signaling PRRs and are an important element of the innate immune system, have an undeniable role in pathogenesis of many immunopathological diseases.
chronic spontaneous urticaria, biomarkers, Toll-like receptors, innate immunity
1. Amelia Licari, Sara Manti, Salvatore Leonardi, Domenico Minasi, Carlo Caffarelli, Fabio Cardinale, Michele Miraglia Del Giudice, Amelia Calvani, Giorgio Ciprandi, Marseglia Gian Luigi. Biologic drugs in chronic spontaneous urticarial // Acta Biomed. – 2021; 92 (Suppl 7): e2021527.
2. Carmen-Teodora Dobrican, Ioana Adriana Muntean, Irena Pintea, Carina Petricău, Diana-Mihaela Deleanu, Gabriela Adriana Filip. Immunological signature of chronic spontaneous urticaria (Review) // Exp Ther Med. – 2022 Jun; 23(6): 381.
3. Futata E., Azor M., Dos Santos J. et al. Impaired IFN-αsecretion by plasmacytoid dendritic cells induced by TLR9 activation in chronic idiopathic urticarial // Br J Dermatol. – 2011. – Vol. 164. – № 6. – R. 1271–1279.
4. Sorokina E.V., Sivakova N.G., Ahmatova E.A., Mitrofanova N.N., Shodova S.A., Ahmatova N.K. Primenenie polivalentnogo bakterial'nogo lizata v kompleksnoy terapii hronicheskoy krapivnicy // Zhurn. mikrobiol. – 2019, № 5, S. 34–39.
5. Sorokina E.V., Egorova N.B., Masyukova S.A., Ahmatova N.K. Mikrobnye antigeny v terapii dermatozov. – 2018. – 304 s.
6. Sorokina E.V., Ahmatova N.K., Golovinov A.I. Osobennosti ekspressii TLRs u bol'nyh hronicheskoy idiopaticheskoy krapivnicey v hode immunoterapii // Rossiyskiy immunologicheskiy zhurnal. – 2014, tom 8(17). – № 2. – C. 203–210.
7. Sorokina E.V., Sivakova N.G., Ahmatova N.K., Shodova S.A. Effektory vrozhdennogo immuniteta pri hronicheskoy spontannoy krapivnice // Klinicheskaya dermatologiya i venerologiya. – 2020; 19(3): 337–342.
