Russian Federation
Russian Federation
Russian Federation
Russian Federation
Russian Federation
Microglia is a key regulatory factor within the central nervous system. Study of those cells’ response to herpes simplex virus 1 is of particular interest. When they are infected with herpesvirus, innate immunity receptors are activated, which leads to the synthesis of cytokines and microglia polarization.
microglia, herpes simplex virus 1
1. Amor S., McNamara N.B., Gerrits E. et al. White matter microglia heterogeneity in the CNS // Acta Neuropathol. – 2022; 143(2):125–141.
2. Thomas Broome S., Louangaphay K., Keay K.A. et al. Dopamine: an immune transmitter // Neural Regen Res. – 2020; 15(12):2173–2185.
3. Masuda T., Sankowski R., Staszewski O. et al. Microglia heterogeneity in the single-cell era // Cell Rep. – 2020. – Vol. 30. – N 5. – P. 1271–1281.
4. Nakagawa Y., Chiba K. Role of microglial m1/m2 polarization in relapse and remission of psychiatric disorders and diseases // Pharmaceuticals (Basel). – 2014. – Vol. 7. – N 12. – P. 1028–1048.
5. Patrycy M., Chodkowski M., Krzyzowska M. Role of Microglia in Herpesvirus-Related Neuroinflammation and Neurodegeneration // Pathogens. – 2022; 11(7):809.
6. Moussaud S., Draheim H.J. A new method to isolate microglia from adult mice and culture them for an extended period of time // J. Neurosci. Methods. – 2010. – Vol. 187. – N 2. – P. 243–253.
7. Louis K.S., Siegel A.C. Cell viability analysis using trypan blue: manual and automated methods // Methods Mol. Biol. – 2011. – Vol. 740. – P. 7–12.
8. McCarthy M.K., Procario M.C., Twisselmann N. et al. Proinflammatory effects of interferon gamma in mouse adenovirus 1 myocarditis // J Virol. – 2015; 89(1):468–479.
9. Tao W., Zhang G., Liu C. et al. Low-dose LPS alleviates early brain injury after SAH by modulating microglial M1/M2 polarization via USP19/FOXO1/IL-10/IL-10R1 signaling // Redox Biol. – 2023; 66:102863.
10. Kamphuis W., Kooijman L., Schetters S. et al. Transcriptional profiling of CD11c-positive microglia accumulating around amyloid plaques in a mouse model for Alzheimer's disease // Biochim. Biophys. Acta. – 2016. – Vol. 1862. – N 10. – P. 1847–1860.
11. Lopez C. Genetics of natural resistance to herpesvirus infections in mice // Nature. – 1975 Nov 13; 258(5531):152–3.
12. Guo S., Wang H., Yin Y. Microglia Polarization From M1 to M2 in Neurodegenerative Diseases // Front Aging Neurosci. – 2022 Feb 16; 14:815347.
13. Katzilieris-Petras G., Lai X., Rashidi A.S. et al. Microglia Activate Early Antiviral Responses upon Herpes Simplex Virus 1 Entry into the Brain to Counteract Development of Encephalitis-Like Disease in Mice // J Virol. – 2022; 96(6):e0131121.
14. Muench H.R. A simple method of estimating 50 per cent end points // Am J Hyg. – 1938. – T. 27. – S. 493–497.
15. Zhang W., Xiao D., Mao Q. et al. Role of neuroinflammation in neurodegeneration development. Sig Transduct Target Ther 8, 267 (2023). https: //doi.org/10.1038/s41392-023-01486-5
