Federal State Budgetary Institution of Higher Professional Education "Central State Medical Academy" (Department of Anesthesiology and Resuscitation, Professor)
Russian Federation
Federal State Budgetary Institution of Higher Professional Education "Central State Medical Academy" (Department of Anesthesiology and Resuscitation, Head of Department)
Russian Federation
Some medicines prescribed in the framework of a comprehensive treatment of various diseases cause nephrotoxicity in patients undergoing treatment in a hospital and resuscitation and intensive care unit. In 14–27% cases of nephrotoxicity development an acute kidney injury was observed. Use of biomarkers allows early detection of initial signs of nephrotoxicity and acute kidney injury. Reasonable approach to prescription of medicines, assessment of risk factors and abandoning of polypharmacy are the fundamentals of prevention of nephrotoxicity development.
nephrotoxicity, biomarkers, acute kidney injury
1. Weiss R., Meerscl1 M., Pa,1enstiidt H.J., Zarbock A. Asnte Kidney lnjnry: A Freqnently U11deresti111ated Rg0Yen1 i11 Perioperative Medicine // Dtsch ArzteY lnt. - 2019; 116(49): 833-842. Doi:https://doi.org/10.3238/arzteY.2019.0833
2. Petejova N., Marti11ek A., Zadrazil J. et al. Asnte Kidney l11jnry i11 Septic Patie11ts Treated 'u Selected Nepl1rotoxic Altibiotic Agepts-Pathophysiology and Bio111arke1·s-A Review // lnt J Mol Sci. - 2020; 21(19): 7115. Doi: I0.3390/ijms21197115
3. Pegazella M.A., Rosper M.N. Drng-Lndnced Acute Kidley lnjury // Clin J An1 Soc Nephrol. - 2022; 17(8): 1220-1233. Doi: I0.2215/CJN.11290821
4. Joyce E.L., Kape-Gill S.L., Fnhmia11 O.U., Kellu111 J.A. Drng-associated actite kidney i11jnry: \vho's at 1·isk? // Pediatr Nephrol. - 2017; 32( 1 ): 59-69. Doi:https://doi.org/10.1007/s00467-016-3446-h
5. Bleykdi S. (red.) Pochechnaya nedostatochnost' i zamestitel'naya terapiya (Kompetentnoe lechenie kriticheskih sostoyaniy) / Per. s angl. A.V. Bep1cheva, E.A. Stec1oka // Pod red. E.A. Stec1oka. - M.: Izdatel'skiy dom Vidar-M. - 2013. - 160 s.
6. Pa1111u N., Nadim M.K. A11 overvie"' of drng-indnced acute kidney injnry // Crit Care Med. - 2008; 36 (4 Suppl): S216-23. Doi:https://doi.org/10.1097/SSM.O'013e318168e375
7. Chen A.U., Deng S.U., Calvacl1i-Prie10 R. et al. A Large-Scale Multicenter Retrospective Stndy on Nepl1rotoxicity Associated With En1pi1·ic Broad-Spectrn,n Antibiotics i11 Critically 111 Patients // Chest. - 2023; 164(2): 355-368. Doi: 10.1 O l 6/j.chest.2023.03.046
8. Blevins A.M., L.ashinsky J.N., McCan11no11 S. et al. lncidence of Act1te Kidney l11jnry i11 C,·itically 111 Patients Receivipg Va11co111yci11 with Co11comita111 Piperacilli11-Tazobactam, Cefepime, or Me1·opene111 // Aptimicrob Agents Cl1e1nother. - 2019; 63(5): e02658-18. Doi: 1 O.1128/AAS.02658-18
9. Tang J., Yang N., Rap S. et al. The renal da1nage and 1nechanis1ns 1·elevant to antituinoral dgugs // Front Opsol. -2023; 13: 1331671. Doi:https://doi.org/10.3389/fo11c.2023.1331671
10. Antonion T., Macdopald E.M., Hollands S. et al. Protop pt1mp inl1ibitors and tl1e risk of asnte kidney injury in older patients: a popt1lation-based col,ort study // CMAJ Open. - 2015; 3(2): e 166-171. Doi: 1 O.9778/cn,ajo.20140074
11. Lazap1s V., Shep U., Wilsop F.P. et al. Proton Rnmr lnl1i'ito1· Use and tl1e Risk of Ch1·011ic Kidney Disease // JAMA lptem Med. - 2016; 176(2): 238-246. Doi: 10.100l /jan1ai11tem1ned.2015.7193
12. Parmat· M.R., Kaleen1 S., San1uganatl1an R. et al. l1npact of Proton Rnmr lphi'itors op Kidney Fnpction and Ch1·onic Kidney Disease Progression: A Syste1natic Revie"' // Ct1rens. - 2023; 15(12): e49883. Doi: I0.7759/ct1reus.49883
13. Hart E., Dnpn T.E., Feners1ei11 S., Jacobs D.M. Proton Rnn1r lphi'itors ai1d Risk of Asnte and Chropic Kidney Disease: A Retrospective Cohort Stt1dy // Phar1nacotl1erapy. - 2019; 39(4): 443-453. Doi:https://doi.org/10.1002/phar.2235
14. Pickkers R., Dapnon M., Hoste E. et al. Acute kidney injt1ry in the critically ill: an npdated revie,v op pathophysiology apd 111anagen1ent // lntepsiveCareMed. - 2021; 47(8): 835-850. Doi:https://doi.org/10.1007/sOO 134-021-06454-7
15. Berglnpd F., Eilertz E., Nin1mersjo F. et al. Act1te apd long-tem, renal effects after iodipe contrast 1nedia-enha11ced compnterised 101nography in the critically ill-a retrospective 'i-ceptrc cohort study // Eur Radiol. - 2024; 34(3): l 73Crl 745. Doi:https://doi.org/10.1007/s00330-023-10059-7
16. Hisa,nune R., Yamaka\va K., U1ne1nnra U. et al. Association Ve1,,,ee11 IV Contrast Media Ehrosnge and Asnte Kidpeu lnjury in Patients Requiring Emerge11cy Ad111issio11: A Natio11,vidc Observational Stndy in Japa11 // Crit Sage Explor. - 2024; 6(9): el 142. Doi:https://doi.org/10.1097/SSE.0000000000001142
17. Klein S.J ., Bra11dt11er A.K., Lehner G.F. et al. Bio1narkers for prediction of gepal replace111ent tl1erapy in acute kidney injnry: a syste1natic review and meta-analysis // lnte11sive Sage Med. - 2018; 44(3): 323- 36. Doi:https://doi.org/10.1007/s00134-018-5126-8



